For a long time, evolutionary biologists have thought that the genetic mutations that drive the evolution of genes and proteins are largely neutral: they're neither good nor bad, but just ordinary ...

Kern agrees: The neutral mutations are still neutral—but they are not behaving as neutral theory would predict. Purifying selection at linked sites, he wrote, would “add noise to allele frequencies ...

For more than half a century, many biologists have leaned on the neutral theory of molecular evolution to explain how DNA and proteins change over time. The idea grew from early work in the 1960s, ...

This important study introduces a new biology-informed strategy for deep learning models aiming to predict mutational effects in antibody sequences. It provides solid evidence that separating ...

ANN ARBOR—For a long time, evolutionary biologists have thought that the genetic mutations that drive the evolution of genes and proteins are largely neutral: they're neither good nor bad, but just ...

Cancer does not develop overnight. It can take decades for cancer-promoting changes in the genome to eventually lead to the formation of a malignant tumor. Researchers at the German Cancer Research ...