Bacterial topoisomerase inhibitors represent a promising class of antimicrobial agents that target essential enzymes involved in DNA replication and maintenance. By inhibiting enzymes such as DNA ...

E. coli divides faster than it can replicate its genome, while simultaneously expressing its genes. Scientists recently revealed the intricate molecular coordination that makes this possible. “It’s as ...

Red arrows indicate the DNA repair pathways that are known to aid bacterial survival as persisters and gamblers in the presence of fluoroquinolones. Blue color arrow indicates downregulation, while ...

Two bacteria are sitting near free-floating DNA. Suddenly, one bacterium shoots out a long appendage, latches onto a DNA fragment and reels in its catch. It happens fast, but it’s clear: this organism ...

Researchers from Durham University, Jagiellonian University (Poland) and the John Innes Centre have achieved a breakthrough in understanding DNA gyrase, a vital bacterial enzyme and key antibiotic ...

Researchers at Utah State University have reported a previously unrecognised CRISPR immune response in which a bacterial ...

Researchers uncovered a previously unknown CRISPR immune response in bacteria that targets transfer RNAs. The newly ...